We have a new in vivo efficacy model available for Inflammatory bowel disease, like ulcerative colitis and Crohn disease mice model. This is a mice model, where colitis is induced with dextran sodium sulfate (DSS).
“Crohn’s disease causes inflammation of the digestive system. It is one of a group of diseases called inflammatory bowel disease. The disease can affect any area from the mouth to the anus. It often affects the lower part of the small intestine called the ileum.”National Institute of Diabetes and Digestive and Kidney Diseases
The acute DSS colitis model in susceptible mice strains is particularly useful to study the contribution of innate immune mechanisms of colitis.
The Average Colitis Index (ACI) is calculated, including the body weight, faeces consistency and faecal blood. Experimental groups were compared to healthy controls that were access to normal tap water. The results were evaluated statistically.
See more on our Gastro-Intestinal models on this page and an overview of our in vivo disease models on this link.
