Cardiovascular safety

Related services

• Toxicity and safety models
• Metabolites in safety testing (MIST)
• CYP identification, inhibition and induction
• Metabolite identification and stability
• Pre-clinical pharmacokinetics
• ONTOMINE - In silico bioactivity, adverse effect and toxicity screening for small molecules and metabolites
• ONTOMINE ADME - In silico models for logP, logD, logS, pKa

Cardiovascular safety evaluation by ECG, HR and BP

Cardiovascular safety assessments examine the peripheral vasculature system, heart, proarrhythmic risk and related effects of cardiovascular performance. Due to its importance, cardiovascular safety assessment is part of core safety package for development of new pharmaceuticals. We provide our customers with the cardiovascular safety assessment using telemetry methods on rats and guinea-pigs. Telemetry allows monitoring of blood pressure, heart rate and electrocardiogram from conscious, unrestrained animals.

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Cardiovascular safety evaluation of ECG and QT prolongation

In addition to the telemetry based cardiovacular safety assessment, we also offer ECG and QT prolongation measurements from anesthetized animals.

Please follow this link to retrieve a detailed fact sheet of the ECG and QT prolongation safety service

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