Chat with an expert
SBW News
- Our participation in R&D projects for new in vivo methods and models: diabetes, obesity, cancer, PK and BBB
- SBW publication supporting Animal wellfare- 3´R principles
- Three long-term phase III oncology studies analysed by SBW/4Pharma
- Meet us in Bio International Convention, May 3-6, 2010 in Chicago, IL
- SBW is recruiting
- Early alert: In vitro genotoxicty studies to become available in March
- SBW strong also in proteomics services
- SBW Roadshow in Medicon Valley
- SBW Roadshow in Stockholm area and Uppsala
- Large customers reward in Feb-May'10 get an amzaing Apple iPAD !
Central nervous system models
Related services
|
Alzheimer's diseaseScopolamine has been proved to impair memory acquisition and retrieval in human and rats. As cognitive dysfunction is a central feature of Alzheimer's disease, scolapamine induced memory impairment model in rats is considered to be a good model for Alzheimer's disease. Our scopolamine induced Alzheimer's model assesses memory function by the Morris water maze. The Morris water maze task requires the rat to learn the location of a hidden escape platform in a large pool of water by cues available in the environment to form a spatial map. Short term memory test: Radial maze testRadial maze test provides an estimation of the animal’s spatial learning and memory. This test is generally used to assess the effect of test substance on the short term memory. Radial maze test provides an easy way to study the effects of drugs, brain damage, or diseases such as epilepsy, Parkinson’s disease and Alzheimer’s disease, on spatial learning and memory in rodents.
Parkinson's diseaseParkinson’s disease is a progressive movement disorder marked by tremors, rigidity, slow movements (bradykinesia), and posture instability. It occurs when neurons in one of the movement-‐control centers of the midbrain begin to die for unknown reasons. The mechanisms leading to the loss of these neurons, however, are largely unknown. Our 1-‐methyl-‐4-‐phenyl-‐1,2,3,6-‐tetrahydropyridine (MPTP) induced Parkinson's model produces a severe and persistent loss of nigrostriatal neurons resulting in dopamine deletion and locomotor impairment, and thus replicates the characteristics of the pathology of Parkinson’s disease. Epilepsy - pictotoxin, kainic acid or theophyllin inducedEpilepsy is a CNS disorder with sudden, unprovoked seizures. Seizures are classified into partial seizures with focal or local cortical origin and generalized seizures involving the whole brain from the onset as convulsive or non-convulsive in nature. We offer a mice epilepsy model which is induced with either pictotoxin, kainic acid or theophyllin with Diazepam used as a reference anticonvulsant agent. This model is used for efficacy testing of new anti-epileptic compounds. Epilepsy - proconvulsant / anticonvulsant determination using pentyelenetetrazol (PTZ) induced clonic and tonic convulsionsPentyelenetetrazol (PTZ) is a frequently used chemical for induction of convulsive seizures in mice. PTZ induced seizures are blocked by Diazepam. We offer a mice epilepsy model which is induced with PTZ with Diazepam used as a reference anticonvulsant agent. This model is used for efficacy testing of new anti-epileptic compounds. Epilepsy - electroshock induced convulsionThe maximal electroshock (MES) model induces convulsive seizures by applying electric current to the brain, which initiates seizures spreading throughout the CNS. Our MES epilepsy model uses phenytoin as a reference agent, capable of blocking the MES seizures. This model is used for efficacy testing of new anti-epileptic compounds. Other in vivo models of CNS diseasesIn addition to the models described above, we also provide the following CNS related models
|
Please follow this link to retrieve a detailed fact sheet of the scolapamine induced Alzherimer's model