Expertise and platforms

• Discovery informatics
• Discovery biology
• ADME/DMPK
• In vivo disease models
• Pre-clinical safety and toxicology
• Clinical trials
• Functional food ingredients
• Chemical safety (REACH)

Expertise and platforms

Expertise

SBW provides a comprehensive spectrum of platforms and services for drug research, functional food ingredients and chemical safety industries. Our expertise covers the following areas:

• Discovery informatics
• Discovery biology
• ADME/DMPK
• In vivo disease models
• Pre-clinical safety and toxicology
• Clinical trials
• Functional food ingredients
• Chemical safety (REACH)

Instrumentation

We have available the latest instrumentation for our various platforms. The key pieces of models and instrumentation is:

Proteomics platforms

• MALDI-TOF/TOF (Bruker Ultraflex II)
• Hybrid triple quadrupole MS:es with linear ion trap interphased with online LC (Thermo LTQ XL)
• Electrospray Ultra-High Resolution tandem TOF (UHR-Qq-TOF) (Bruker MaXis) with online LC

Genomics platforms

• Based on Affymetrix technologies

Small molecule platforms

• UPLC/TOF-MS, HPLC/TOF-MS, UPLC/MS/MS, HPLC/MS/MS and HPLC/RAD (Waters)
• LC-MS/MS Linear ion-trap (Thermo LTQ XL)
• 300, 400 MHz NMR (Bruker DPX)
• 500 MHz LC-NMR, GC-MS, FTIR with IR microscope, CD, CE

In vivo platforms

• Over 40 different disease models in CVD, diabetes, CNS, GI etc. areas, safety and toxicology evaluations
• Whole animal imaging: IVIS fluorescence (rodents) and SPEC-CT with four heads (rodents, rabbits) (Q2/10)
• Hematology, clinical chemistry, histology, microscopy and toxicokinetics instrumentation
• Individually Ventilated Cage (IVC) -system, SPF-facilities, laboratories for behavioral studies and individual metabolic cages.
• Facilities have adjustable environmental conditions, including temperature and light conditions according to project requirements

Computational platforms

• Molecular modeling workstations
• Custom programming, statistics and data mining platforms
• Own patented QSPR platform (Ontomine) for small molecule bioactivity, adverse effect and tox predictions
• Access to one of worlds largest supercomputer for most demanding virtual screening, simulation etc. jobs

All our studies are tailored on customer’s request. We also offer development a novel disease models, including the analytics capabilities in SBW, including genomics, proteomics, live imaging, gross and histopathology.

Follow this link to retrive a brochure of SBW platforms and business models.