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PAMPA, Caco-2 and skin permeability
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We provide various in vitro models for assesing the compounds ability to traverse various biological membranes. These models are used to study the bioavailability and distribution in in vitro conditions.
PAMPA membrane permeationPAMPA assay provides information on the ability of the compound to traverse through artificial phospholipid based membrane. Use of artificial membrane ensures the transport is done by passive diffusion. Caco-2 monolayer permeationThe human colon carcinoma Caco-2 cells provides a way to measure the compounds ability to be absorbed from small intestine in apical to basolateral direction. Human skin permeationPermeation study on human cadaver skin to characterise compounds and formulations intended for topical administration. |
Please follow this link to retrieve a detailed fact sheet of the PAMPA service