Verifying the efficacy of your lead molecules is of crucial importance prior to investing further on lead optimization. Disease models help you to select molecules with therapeutic potential for drug development.
We support you in efficacy screening and proof-of-concept studies with validated disease models and state-of-art techniques. Our comprehensive research approach yields more information from a single study. This allows the elimination of unsuitable compounds and provides valuable input for designing regulatory studies.
Type I and II diabetes and obesity
Our diabetes models include Goto-‐Kakizaki (GK) rat, Zucker Diabetic Sprague Dawley (ZDSD) rat, Zucker Diabetic Fatty (ZDF) rat and Diet induced obesity (DIO) in rodents as well as STZ induced type 1 diabetes. Our models come with customized during- the study and end‐point analysis, like non invasive NMR-‐MRI based body composition analysis of living animals, blood glucose, insulin, triglycerides and free fatty acid levels, hunger/satiety hormones (like leptin, GLP-‐1, glucagon, ghrelin), oral glucose tolerance test as well as monitoring of the gross parameters like body mass, food and water intake etc.
 More on our diabetes and obesity models |
Cardio-vascular, hypertension and stroke models
Hypertension is the most common cardiovascular disease and one of the risk factors of stroke. Our models include Spontaneously Hypertensive Stroke Prone (SHRSP) rat as a spontaneous stroke model, Spontaneous Hypertensive Rat (SHR) and Dahl/Salt Sensitive (Dahl/SS) rat as models of hypertension and Mice homozygous for the Ldlr(tm1Her) mutation having elevated serum cholesterol levels. Cardiovascular parameters such as blood pressure and heart rate can be measured in conscious, free-‐moving rats/guinea pigs using telemetry systems or tail cuff. In addition we monitor clinical signs and general behavior as well as the gross parameters like body mass, food and water intake etc. Also parameters like insulin resistance, insulin levels, triglyceride and cholesterol levels, hypercholesterolemia, cardiac hypertrophy and heart failure can be measured.
Read more on our cardiovascular and stroke models |
Oncology
IN onclogy we provide both xenograft as well as induced models. DMBA induced mammary carcinoma in rats is considered to resemble well human breast cancer, since the blood vessels and lymph duct surrounding the tumor tissue resemble those in human breast cancer. As xenograft models we work both as orthotopic or subcutaneous implantation of cancer cells/cell lines, providing models for many different cancer types.
In xenograft models, we measure tumor size just before each injection time point as well as an end-point after the experiment. Immediately after termination of the experiment, liver, spleen, lungs, urinary bladder, and kidneys are removed, examined visually for cancer metastases, and fixed in formalin for later analyses. By using specific luciferase labeled tumor cells and specific non-invasive in vivo live imaging (IVIS), the generation of distant metastasis from the primary tumor can be followed throughout the experiment period.
Read more on our oncology models |
Pain
In pain area, we operate with various models, including mechanical hyperalgesia, tactile allodynia and cold allodynia (acetone), both as individual models as well as related to disease progression in different other disease models.
Read more on our pain models |
Gastro-intestinal diseases
Induced by ethanol, HCl or NSAIDs (indomethacin or acetylsalicylic acid).
Read more on our GI models |
Dermatology
Other disease models include TPA induced acute inflammatory reaction with erythema, edema and leucocyte infiltration. Repeated applications of TPA leads to prolonged inflammatory reaction with increase in ear weight, epidermal hyperplasia, resembling psoriatic condition.
Read more on our dermatology in vivo disease models. |
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All our studies are tailored on customer’s request. We also offer development a novel disease models, including the analytics capabilities in SBW, including genomics, proteomics, non-invasive live-imaging, gross and histopathology, biochemical, clinical chemistry, hematology etc.
Follow this link to retrive a comprehensive list of our disease models
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