Dermatology

Acute or chronic skin inflammation

12-O-tetradecanoylphorbol-13-acetate (TPA) applied on mouse ear is able to induce an acute inflammatory reaction with erythema, edema and leucocyte infiltration. Repeated applications of TPA lead to prolonged inflammatory reaction with increase in ear weight, epidermal hyperplasia.

Our TPA induced skin inflammation model is used to asses the anti-inflammatory efficacy of new compounds and formulations.

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