In vivo models of Type I and II diabetes and complications
Non-insulin dependent Diabetes Mellitus – ZDSD model
Zucker Diabetic Sprague Dawley (ZDSD; Reinwald et al., Am J Physiol Endocrinol Metab. 296, 2009) is a new model for the discovery and development of therapies targeting obesity, hyperglycemia, insulin resistance and hyperlipidemia, concomitantly leading to the development of Type II diabetes in the model. The ZDSD Rat model of Type 2 diabetes/obesity more closely resembles the human condition than other rodent models.
Based on our experience, ZDSD spontaneously exhibits obesity, hyperglycemia, insulin resistance and hyperlipidemia, while having no defects in Leptin or Leptin receptor. The obesity and diabetes can be modulated by diet and can be treated with standard pharmaceuticals as references. In addition, the ZDSD rat expresses the bone, renal and other diabetic complications.
Our ZDSD model includes measurements of the T2DM relevant parameters, like non invasive NMR-MRI based body composition analysis of living animals, blood glucose, insulin, triglycerides and free fatty acid levels, hunger/satiety hormones (like leptin, GLP-1, glucagon, ghrelin), oral glucose tolerance test as well as monitoring of the gross parameters like body mass, food and water intake etc.
Please follow these link to retrieve a detailed fact sheet of the ZDSD diabetes model or to request a quote
Non-insulin dependent Diabetes Mellitus – Goto-Kakizaki model
Goto-Kakizaki (GK) is a non-obese model of non-insulin dependent Diabetes Mellitus (Type 2 Diabetes). GK male rats develop spontaneously human T2DM resembling condition in around 15 weeks of age.
Our GK model includes measurements of the T2DM relevant parameters, like blood glucose, insulin, triglycerides and free fatty acid levels, hunger/satiety hormones (like leptin, GLP-1, glucagon, ghrelin), oral glucose tolerance test as well as monitoring of the gross parameters like body mass, food and water intake etc.
Please follow these link to retrieve a detailed fact sheet of the GK diabetes model or to request a quote
Non-insulin dependent Diabetes Mellitus – Zuker Diabetic Fatty model
Zuker-Diabetic Fatty (ZDF) rats carry a mutation (fa/fa) leading to insulin resistance. When fed with a special diet, the male rats develop a condition closely resembling human non-insulin dependent Diabetes Mellitus (Type 2 Diabetes) and related complications
Our ZDF model includes measurements of the T2DM relevant parameters, like non invasive NMR-MRI based body composition analysis of living animals, blood glucose, insulin, triglycerides and free fatty acid levels, hunger/satiety hormones (like leptin, GLP-1, glucagon, ghrelin), oral glucose tolerance test as well as monitoring of the gross parameters like body mass, food and water intake etc.
Please follow these link to retrieve a detailed fact sheet of the ZDF diabetes model or to request a quote
Diet induced obesity model
Diet induced obesity (DIO) is a mice model, where the animals are fed on special high fat diet. Obesity emerges as the result of the imbalance between digested and consumed energy. The obesity comes with other conditions, like hyperglycemia, hyperlipidemia and coronary-heart disease.
Our DIO model includes measurements of the obesity relevant parameters, like non invasive NMR-MRI based body composition analysis of living animals, blood glucose, triglycerides, insulin, free fatty acid levels, hunger/satiety hormones (like leptin, GLP-1, glucagon, ghrelin), as well as monitoring of the gross parameters like body mass, food and water intake etc.
Please follow these link to retrieve a detailed fact sheet of the DIO diabetes model or to request a quote
Diabetic neuropathy / neuropathic pain model
Diabetes mellitus often leads over the long term to serious consequences, especially in the insulin sensitive tissues (retina, neurons, kidneys) as well as functional and structural CNS disorders. Diabetic peripheral neuropathic pain is a common secondary complication of diabetes.
Streptozotocin (STZ) is antibiotic that can also cause destruction of the pancreatic beta-cells, thus capable of inducing insulin-dependent Diabetes Mellitus (Type 1 Diabetes). Our diabetic neuropathy model is a STZ induced diabetic neuropathy rat model.
Our diabetic neuropathy model includes measurements of the relevant parameters, like non invasive NMR-MRI based body composition analysis of living animals, blood glucose levels, as well as pain paramaters, motor nerve conduction velocity and sciatics nerve blood.
Please follow these link to retrieve a detailed fact sheet of the diabetic neuropathy model or to request a quote
Oral glucose tolerance test
Diabetic conditions appear when either the pancreas does not secrete enough insulin or when the body is unable to respond to the insulin signal. Hyperglycemia is a common effect of diabetes and can lead to e.g. damage of nerves and blood vessels.
Our oral glucose tolerance test (OGTT) is done during a period of 28-days, when rats are fed with glucose by oral gavage. The blood glucose levels are followed along the study, allowing the studies of compounds efficacy in maintaining the normal blood glucose levels.
Please follow these link to retrieve a detailed fact sheet of the OGTT test or to request a quote
The studies are always tailored to the needs of the project, and can include a large variability of different analytics. Contact us from this link for more details.
