In vivo toxicology

Related services

• Toxicity and safety models
• Metabolites in safety testing (MIST)
• CYP identification, inhibition and induction
• Metabolite identification and stability
• Pre-clinical pharmacokinetics
• ONTOMINE - In silico bioactivity, adverse effect and toxicity screening for small molecules and metabolites
• ONTOMINE ADME - In silico models for logP, logD, logS, pKa

Tox Screen in rodents

Tox Screen is a service for screening lead series or different dose levels based on their in vivo toxicological properties in rodents. This service has been designed to yield data that allow elimination of unsuitable compounds early at the discovery stage and also to provide input for planning regulatory toxicological studies.

Please follow this link to retrieve a detailed fact sheet of the Tox screen in mice service

Please follow this link to retrieve a detailed fact sheet of the Tox screen in rats service

Maximum tolerated dose in rodents

This study is for identification of Maximum Tolerated Dose of lead compounds in rodents. Our service has been designed to yield valuable data on dose levels for planning regulatory toxicological studies.

The MTD toxicity study is available both as non-GLP and GLP.
Please follow this link to retrieve a detailed fact sheet of the MTD in mice service

Please follow this link to retrieve a detailed fact sheet of the MTD in rats service

Repeated dose toxicity in rodents

We offer the repeated dose toxicity studies of 28-days and 90-days. Repeated dose studies are required for IND submission as well as in other regulated areas. We follow the OECD guidelines for conducting the repeated dose toxicity studies.

The repeated dose toxicity study is available both as non-GLP and GLP.

For more information, contact us from this link.