ADME/DMPK and Lead Optimization

 

Our areas of ADME/DMPK expertise

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All our studies can also be tailored on customer’s request.
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Background

The lead optimization process aims to improving the hit/lead molecules properties for ADME profile, reduction of off-target effects and improved efficacy. Series of compounds with altered properties are assayed and their drug like properties are optimized.

Lead optimization process is balancing between multiple properties, including efficacy, safety and toxicity, chemical stability, metabolite formation, routes and stability, solubility and absorption. Ability to handle this process requires expertise and technologies from multiple disciplines.

A key aspect in ADME/DMPK lead optimization studies is to have a deep understanding on the various methods and study types, the aims of the discovery project and the characteristics of the molecule(s). The different ADME studies, including in vitro and in vivo, should not be seen as independent experiments, but as part of the whole process to rank compounds and optimize their properties, to be developed from the typical efficacious  hits to drug like candidates.

Going with a service provider that only has the deep expertise in some of these areas easily gets lost into expanding in studies in the particular expertise area, instead of understanding the whole approach of the lead-optimization project.

SBW Lead optimization platform

Our uniqueness comes from our ability to provide our customers with comprehensive expertise and technologies for the lead optimization process. We help our customers in all stages of the lead optimization process – planning the projects and individual studies – executing the in vitro and in vivo studies – interpreting the results and suggesting the followup actions. This is part of our Scientific Account Management strategy, where the studies are tailored for each account, project and molecule.

However, not just providing the highest expertise in these areas, our aim is to help our customers to understand the whole lead optimization process and plan each project with the right sequence of the various in vitro and in vivo studies, including the physicochemical studies, metabolism and drug interaction studies, permeation studies, pharmacokinetics studies, toxicology and safety studies as well as the in vivo efficacy studies. This also includes the scientific judgment of selecting the correct preclinical in vivo species for the various studies.

Our expertise can help you also to understand the studies done previously in other laboratories and how the results should interpreted – what is behind the numbers of the done analytics and what should be the next steps forward. In addition, we help you to understand the results from different done studies to see the whole picture in depth and plan the next steps. As a point differentiating us from other CROs, is our broad in deep understanding and daily operations in the various in silico, in vitro and in vivo areas. We are able to provide all this cross-disciplinary expertise by our Scientific Account Management process, get you forward faster, doing the correct tests and avoiding possibly un-necessary studies.