Metabolite identification and stability

Related services

We provide our customers with world-class expertise in the various areas of small molecule drug metabolism

Metabolism studies in vitro

Metabolic stability
Metabolite identification: biotransformations
Metabolite identification: structural analysis (MS and NMR)
Kinetics of metabolic stability
Kinetics of metabolite formation
Prediction of in vivo kinetics
Identification of rate-limiting CYP enzyme
Identification of rate-limiting UGT enzyme
Metabolic profiles human vs animals
Organ specific metabolism
Reactive metabolite trapping

Metabolism studies in vivo

Bioavailability
Metabolite identification: biotransformations
Metabolite isolation
Metabolite identification: structural analysis (MS and NMR)
Tissue homogenate analysis
Pharmacokinetic calculations for parent and metabolites
Quantitative bioanalysis (DMPK)
Vehicle finding, vehicle stability
Validation of bioanalytical methods

MetaboPilot

Quick and easy-to-order study to find out metabolic stability and main biotransformations of NCE in human. All phase I and II metabolism pathways are enabled.
Please follow this link to retrieve a detailed fact sheet of the MetaboPilot service

MetStab

Straightforward study to characterize metabolic stability of NCEs and to calculate enzyme kinetic values for intrinsic clearance and in vivo prediction. Used for hit molecule characterisation, lead molecule selection and to aid lead optimisation.
Please follow this link to retrieve a detailed fact sheet of the MetStab service
Please follow this link to retrieve a detailed fact sheet of the MetStab in hepatocytes service
Please follow this link to retrieve a detailed fact sheet of the MetStab in homogenates service
Please follow this link to retrieve a detailed fact sheet of the MetStab in microsomes service

MetabolD (includes MetStab)

Comprehensive study to find out detailed human in vitro metabolite profile of NCE. Metabolic stability of NCE and enzyme kinetic values for in vivo prediction is included. Used for drug candidate characterisation, lead molecule selection and to aid lead optimization.

MetaboPilot, MetStab and MetaboID can be done in multiple species to be able to compare metabolic characteristics in human and different animal species. Can be used for selection of toxicology animal models. Available animal species include mouse, rat, guinea pig, rabbit, dog, monkey and minipig.
Please follow this link to retrieve a detailed fact sheet of the MetaboPilot service
Please follow this link to retrieve a detailed fact sheet of the Metabolite ID in vivo service

Reactive metabolite characterization

Reactive drug metabolites are known to be on e of the factors behind unexpected drug-induced toxicity and therefore their identification early in the drug discovery process is of big importance.
Please follow this link to retrieve a detailed fact sheet of the Reactive metabolite characterization service
Also see our comprehensive MIST (metabolites in safety testing) service offering from this link.

HepatoPlate

Comprehensive metabolism and drug interaction study on fresh or cryopreserved, human or animal hepatocytes in 24-well plate format. Information content includes metabolic stability, metabolite identification, accumulation of parent and metabolites to hepatocyte cells, inhibition and induction.
Please follow this link to retrieve a detailed fact sheet of the MetaboPilot service