In vivo pharmacokinetics

Related services

• Computational logP, logD, logS, pKA and BBB predictions
• Experimental logP, logD, logS and pKA analysis
• Plasma protein binding
• In vitro metabolism
• CYP enzyme identification and inhibition
• Metabolite identification
• Metabolite stability
• PAMPA membrane permeation
• CaCO2 and MDCK cell permeation
• Organ specific permeability
• In vivo disease models
• Toxicity and safety models
• Regulatory guidance and consulting
• Biomarker discovery and validation
• Computational bioactivity and toxicology prediciton

We offer complete non-clinical PK / biodistribution studies using different animal species from serum, plasma, urine, faeces and tissue samples.

We also routinely perform in vivo PK studies in dogs, and minipigs.

Administration routes and formulations

Available dose routes include:

• intravenous (also jugular vein catheter)
• oral
• subcutaneous
• intraperitoneal
• dermal administration

Formulation for IV dosing

• Vehicle finding
• Vehicle stability

Bioanalytical services

We provide you with a flexible solution with the possibility to order bioanalytical services and pharmacokinetic calculations, or your project can be limited to study design, dosing and sample collection only.

We provide the PK analytics for both small molecules and proteins/biologics.

Bioanalytical services

• Bioanalytical method validation
• Quantitative bioanalysis (matrices: plasma, serum, urine, tissue homogenate)
• Metabolite identification and profiling
• Pharmacokinetic calculations
• Pharmacokinetic parameters AUC, t1/2, Cl, V, Tmax, Cmax Bioavailability (F)

All our studies are tailored on customer’s request. We also offer development a novel disease models, including the analytics capabilities in SBW, including genomics, proteomics, live imaging, gross and histopathology.

More information

Please follow this link to retrieve a fact sheet of our pharmacokinetics models

Contact us from this link.