Pre-clinical - Toxicology and safety pharmacology

Service areas for safety and toxicology

• In vitro cytotoxicity, cell viability and apoptosis models
• In vitro genotoxicity models
• In vivo toxicity models
• In vivo safety models
• Cardiovascular safety models
• Central nervous system safety models
• Gastro-intestinal safety models
• Respiratory system safety models
• Regulatory guidance and consulting

Related services

• Biomarker discovery and validation
• Pharmacokinetics
• Computational bioactivity and toxicology prediciton
• Computational bioactivity and toxicology prediciton

We support you in the lead optimization and drug candidate selection with toxicology and safety pharmacology services. Our comprehensive research approach yields more information from a single study.

Studies are done either fully under GLP standards or non-GLP with internal SOPs. Study reconstruction is ensured through adequate documentation of study conduct, and archiving of data.

Our toxicology and safety models cover following areas:

• In vitro cytotoxicity, cell viability and apoptosis models
• In vitro genotoxicity models
• In vivo toxicity models
• In vivo safety models
• Cardiovascular safety models
• Central nervous system safety models
• Gastro-intestinal safety models
• Respiratory system safety models
• Regulatory guidance and consulting

All our toxicology and safety service packages can be customized according to the compound class, therapeutic target and the testing model of your compound. We also offer development of novel disease models, including the analytics capabilities in SBW, including genomics, proteomics, live imaging, gross and histopathology.